Northwestern University
Selected Publications
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Chakrabarty, R.P., Van Vranken, J.G., Aoi, Y. et al. Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite. Nature (2026). PMID: 42162436. https://doi.org/10.1038/s41586-026-10564-x.
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Sebo, Z.L., Chakrabarty, R.P., Grant, R.A. et al. Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control. Nat Metab 8, 1291–1304 (2026). PMCID: PMC13303093. https://doi.org/10.1038/s42255-026-01530-y.
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Steinert, E.M., Furtado Bruza, B., Danchine, V.D. et al. Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate. Nat Immunol 26, 1267–1274 (2025). PMCID: PMC12307223. https://doi.org/10.1038/s41590-025-02202-x.
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Reczek, C.R. et al. Metformin targets mitochondrial complex I to lower blood glucose levels. Sci Adv. 10,eads5466 (2024). PMCID: PMC11654692. DOI:10.1126/sciadv.ads5466.
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Stoolman, J.S., et al. Mitochondria complex III–generated superoxide is essential for IL-10 secretion in macrophages. Sci Adv. 11,eadu4369(2025). PMCID: PMC11753406. DOI:10.1126/sciadv.adu4369.
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Stoolman, J.S., Grant, R.A., Poor, T.A. et al. Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation. Nat Metab 6, 1492–1504 (2024). PMID: 39048801. https://doi.org/10.1038/s42255-024-01080-1.
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Han, S., Lee, M., Shin, Y., Giovanni, R., Chakrabarty, R. P., Herrerias, M. M., Dada, L. A., Flozak, A. S., Reyfman, P. A., Khuder, B., Reczek, C. R., Gao, L., Lopéz-Barneo, J., Gottardi, C. J., Budinger, G. R. S. & Chandel, N. S. Mitochondrial integrated stress response controls lung epithelial cell fate. Nature 620, 890–897 (2023). PMCID: PMC10447247. https://www.nature.com/articles/s41586-023-06423-8.
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Billingham, L. K., Stoolman, J. S., Vasan, K., Rodriguez, A. E., Poor, T. A., Szibor, M., Jacobs, H. T., Reczek, C. R., Rashidi, A., Zhang, P., Miska, J. & Chandel, N. S. Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nat Immunol 23, 692–704 (2022). PMCID: PMC9098388. https://www.nature.com/articles/s41590-022-01185-3.