Recent Publications

  1. Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS. Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Science Signaling. 2013; 5; 6:ra8. PMID: 23386745.

  2. Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity.2013; 38:225-36. PMC3582741.

  3. Sullivan LB, Martinez-Garcia E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, Licht JD, Deberardinis RJ, Chandel NS. The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Molecular Cell. 2013 51:236-48. PMC3775267.

  4. Peek CB, Affinati AH, Ramsey KM, Kuo H-, Yu W, Sena LA, Iilkayeva O, Marcheva B, Kobayashi Y, Omura C., Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science. 2013;342(6158). PMID: 24051248.

  5. Glasauer A, Sena LA, Diebold LP, Mazar AP and Chandel NS. Targeting SOD1 reduces experimental non–small-cell lung cancer. J Clin Invest. 2014 124:117-28. PMC3871252.

  6. Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS and Chandel NS. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. eLIFE. 2014 May 13;3:e02242. PMID: 24843020

  7. Chandel NS and Tuveson DA. The promise and perils of antioxidants for cancer patients. N Engl J Med. 2014 371(2):177-8. doi: 10.1056/NEJMcibr1405701.

  8. Schieber M and Chandel NS. TOR signaling couples oxygen sensing to lifespan in C. elegans.  Cell Reports 9(1):9-15. PMID:25284791

  9. Martínez-Reyes I, Diebold LP, Kong H, Schieber M, Huang H, Hensley CT, Mehta MM, Wang T, Santos JH, Woychik R, Dufour E, Spelbrink JN, Weinberg SE, Zhao Y, Deberardinis RJ, Chandel NS, 2016. TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. Molecular Cell 61, 199–209. doi:10.1016/j.molcel.2015.12.002

  10. Hamanaka RB, Weinberg SE, Reczek CR, Chandel NS, 2016. The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia. Cell Reports 15, 451–459. doi:10.1016/j.celrep.2016.03.044

  11. Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS, 2017. The mitochondrial respiratory chain is essential for haematopoietic stem cell function. Nature Cell Biology 19, 614–625. doi:10.1038/ncb3529

  12. Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS, 2017. A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nature Chemical Biology 13, 1274–1279. doi:10.1038/nchembio.2499

  13. Mehta, M. M., Weinberg, S. E., & Chandel, N. (2017). Mitochondrial control of immunity: Beyond ATP. Nature Reviews Immunology, 17(10), 608-620.

  14. Weinberg, S. E., Singer, B., Steinert, E. M., Martinez, C. A., Mehta, M. M., Martínez-Reyes, I., ... Chandel, N. (2019). Mitochondrial complex III is essential for suppressive function of regulatory T cells. Nature, 565(7740), 495-499.

  15. Rodriguez, A. E., Ducker, G. S., Billingham, L. K., Martinez, C. A., Mainolfi, N., Suri, V., ... Chandel, N. (2019). Serine Metabolism Supports Macrophage IL-1β Production. Cell Metabolism, 29(4), 1003-1011.e4.

  16. Diebold, L, Gil, HJ, Gao, P, Martinez, C, Weinberg, S, Chandel, NS. (2019). Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis. Nature Metabolism. 1. 10.1038/s42255-018-0011-x.