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Mitochondria control of physiology and disease

Mission of the lab is to discover new biology linked to mitochondria and metabolism that controls physiological responses and diseases including cancer, viral pneumonia, neurological diseases (Parkinson’s, ALS, and Alzheimer) and aging. A key aspect of this mission is also to train the next generation of “discoverers” in a supportive environment.

Lab News

Lab News


Chandel Receives 2023 Lurie Prize in Biomedical Sciences

Navdeep Chandel, PhD, the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care and of Biochemistry and Molecular Genetics,  has been named a recipient of the 2023 Lurie Prize in Biomedical  Sciences by the Foundation for the National Institutes of Health (FNIH).


For more information about the Lurie Prize in Biomedical Sciences and a list of previous winners, please visit


Understanding Mitochondrial Dysfunction's Impact on Neurological Diseases

Dr. Chandel discusses a recent study that may improve the understanding of mitochondrial dysfunction and its impact on the development of neurological diseases. The study, led by Greg McElroy, also suggests that targeting mitochondrial complex I linked biology could be a promising therapeutic target for neurological diseases.


Mitochondria Regulate Cellular Signaling for Proper Lung Development

Northwestern Medicine investigators have discovered that mitochondria  regulate essential cellular signaling for the development of epithelial  cells in the lungs, cells which are crucial for the exchange of oxygen  and carbon dioxide to avoid respiratory failure, according to findings published in Nature.



Mitochondrial Metabolism Shows Promise as Target for Cancer Therapy

Dr. Chandel discusses recent publications in the lab demonstrating the essential role of the mitochondrial electron transport chain in tumorigenesis and potential therapeutic avenues for targeting mitochondrial metabolism in the clinic.


Highly Cited Researchers List 2018-2022

Twelve faculty with appointments at Feinberg, including Nav Chandel, were named to the 2022 “Highly Cited Researchers”  list, published by Clarivate Analytics. The annual list identifies  investigators who have demonstrated significant influence in their  field through the publication of highly cited publications during the  last decade.

The data in the list is pulled from papers published in science and  social sciences journals from 2011 through 2021. The list includes those  investigators who rank among the top one percent as the most cited for  their subject field and year of publication.




Metabolism, Mitochondria, and Metformin in Health and Disease

In this podcast episode of The Peter Attia Drive, Navdeep Chandel, PhD discusses the role of mitochondria and metabolism in health and disease. Nav also provides insights into the mitochondria as signaling organelles, antioxidants, and Metformin's multifaceted effects on human health, among many topics related to well-being.


The Return of Metabolism

In Episode #226 of SmartDrugSmarts, Dr. Chandel shares his research into the subcellular world of mitochondria, ATP, the Krebs Cycle — and how these esoteric interests translate up into real-world lifespan and quality-of-life differences for us big, adult mammals.

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