Mitochondria as signaling organelles

 

Mitochondria have historically been viewed as a simple energy source for the cell. However, it is becoming increasingly clear that they also play a critical role in signaling for the cell. Our lab studies the many ways in which mitochondria, and metabolism in general, can affect changes in cell functions.

Lab News

Oct 19, 2020

In this episode of JRNLclub, Inma Martinez-Reyes discusses the findings in her recent Nature paper illustrating the essential role of mitochondrial ubiquinol oxidation in tumor growth.

Sep 8, 2020

Dr. Chandel discusses a recent study that may improve the understanding of mitochondrial dysfunction and its impact on the development of neurological diseases. The study, led by Greg McElroy, also suggests that targeting mitochondrial complex I linked biology could be a promising therapeutic target for neurological diseases.

July 23, 2020

Dr. Chandel discusses recent publications in the lab demonstrating the essential role of the mitochondrial electron transport chain in tumorigenesis and potential therapeutic avenues for targeting mitochondrial metabolism in the clinic.

April 07, 2020

In this article, Dr. Navdeep Chandel discusses the potential of Metformin as a drug to combat the COVID-19 pandemic.

November 18, 2019

Mitochondria, the organelle that powers most cells in the body, may be the canary in the coal mine for neurological disease, according to new findings published in the Journal of Cell Biology. Mitochondrial stress and dysfunction have long been suspected as an early step in diseases like Parkinson’s or Alzheimer’s disease, but Navdeep Chandel and collaborators have uncovered a mechanism that may explain how. The study found that mitochondrial stress in neurons can cause an enzyme imbalance that contributes to neuronal dysfunction and death. Reversing this imbalance showed promise in cell models, sketching an outline of a future therapy.

March 29, 2019

Metabolic therapy is showing promise in robbing malignant cells of their primary energy source. In this Op-Ed, Navdeep Chandel discusses the current status and future directions of metabolic therapy in the clinic.

March 18, 2019

Mitochondria are most famous as sources of metabolic energy. But by splitting and combining, they can also release chemical signals to regulate cell activities, including the generation of neurons.

January 16, 2019

Northwestern Medicine scientists have demonstrated that a specific mitochondrial protein complex is essential to the immunosuppressive activity of regulatory T-cells, findings with potential significance for a wide variety of autoimmune diseases.

The study, published in Nature, demonstrated that the suppressive function of regulatory T (Treg) cells was impaired when they had been modified to lack mitochondria complex III, previously known as an essential component of mitochondrial function.

December 07, 2018

Clarivate Analytics has included Navdeep S. Chandel, PhD in their list of Highly Cited Researchers of 2018. This list represents scientists and social scientists who have demonstrated significant influence in the last decade. It recognizes world-class researchers selected for their exceptional research performance, demonstrated by production of multiple highly cited papers that rank in the top 1% by citations for field and year in Web of Science.

December 03, 2018

In this podcast episode of The Peter Attia Drive, Navdeep Chandel, PhD discusses the role of mitochondria and metabolism in health and disease. Nav also provides insights into the mitochondria as signaling organelles, antioxidants, and Metformin's multifaceted effects on human health, among many topics related to well-being.

May 05, 2018

In this podcast by Smart Drugs Smart, Navdeep Chandel, PhD shares his research into the subcellular world of mitochondria, ATP, the Krebs cycle - and how these esoteric interests translate into real-life lifespan and quality-of-life differences for humans.

October 23, 2017

Navdeep S. Chandel's lab has used an innovative gene editing technique to identify the genes that may lead to Parkinson's disease after exposure to paraquat, a commonly used herbicide. This study, which utilized the CRISPR-Cas9 gene-editing tool, serves as a proof-of-concept for using genetic screens to investigate the biology of oxidative stress.

The study was published in Nature Chemical Biology and the first author was Colleen Reczek, PhD, a postdoctoral fellow in Chandel's lab. Other authors include Chandel lab members Hyewon Kong and Inmaculada Martinez-Reyes, PhD.

June 12, 2017

New Northwestern Medicine published in Nature Cell Biology has shown that mitochondria, traditionally known for their role creating energy in cells, also play an important role in hematopoiesis, the body's process for creating new blood cells.

In this study, Navdeep S. Chandel's lab, including postdoctoral fellow Elena Anso, PhD, and graduate students Sam Weinberg and Lauren Diebold demonstrated that mitochondria control hematopoietic stem cell fat by preventing the generation of a metabolite called 2-hydroxyglutarate (2HG). The scientists showed that mice with stem cells deficient in mitochondrial function cannot generate blood cells due to elevated levels of 2HG, which causes histone and DNA hyper-methylation.

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© 2014 Navdeep Chandel.

Northwestern University

Lurie Cancer Center

Feinberg School of Medicine